Laser-activated nanothermolysis of cells

Details Laser-activated nanothermolysis of cells Laser-activated nanothermolysis of cells

2011-08-16

2011-08-16

Reddig, Peter J (Department: 1642)

Nanotechnology

Nanostructure

C977S702000, C530S387100, C530S387700, C424S093100, C424S093700, CD24S158000

Reexamination Certificate

active

07999161

ABSTRACT:
Provided herein are methods and system to increase selective thermomechanical damage to a biological body, such as a cancer cell or cell associated with a pathophysiological condition. The biological body or cancer cell is specifically targeted with nanoparticulates comprising one or more targeting moieties which form nanoparticulate clusters thereon or therewithin. Pulsed electromagnetic radiation, e.g., optical radiation, having a wavelength spectrum selected for a peak wavelength near to or matching a peak absorption wavelength of the nanoparticulates selectively heats the nanoparticulates thereby generating vapor microbubbles around the clusters causing damage to the targets without affecting any surrounding medium or normal cells or tissues. Also provided is a method of treating leukemia using the methods and system described herein.

REFERENCES:
Lapotko et al. (Lasers in Surgery and Medicine Jan. 20, 2005, 36(1): 22-30).

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