Laser ablation/ionizaton and mass spectrometric analysis of mass

Details Laser ablation/ionizaton and mass spectrometric analysis of mass Laser ablation/ionizaton and mass spectrometric analysis of mass

1990-06-01

1992-08-04

Housel, James C.

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

436 85, 436 86, 436 94, 436174, 436181, 364497, 250282, 250288, G01N 2400

Patent

active

051358700

ABSTRACT:
A sample containing one or more compounds of high molecular weight is analyzed by irradiating, with a pulsed laser in vacuum, a substrate coated with a thin frozen film of a solution containing the sample. The laser energy is absorbed at the surface of the substrate, rapidly heating the frozen film and ablating the solvent into a vapor plume which carries into the vapor phase entrained molecules of the sample. The vaporized molecules are ionized and accelerated into a mass spectrometer. Mass spectrometric determination of the masses of the ionized molecules of the sample allows the molecular components of the sample to be identified.

REFERENCES:
patent: 4243881 (1981-01-01), Bethune et al.
patent: 4674878 (1987-06-01), Vo-Dinh
patent: 4802761 (1989-02-01), Bowen et al.
patent: 4920264 (1990-04-01), Becker et al.
patent: 4988879 (1991-01-01), Zare et al.

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