Large-scale synthesis of selective androgen receptor modulators

Details Large-scale synthesis of selective androgen receptor modulators Large-scale synthesis of selective androgen receptor modulators

2011-06-28

2011-06-28

Andres, Janet L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S491000, C560S020000, C562S899000, C564S090000, C564S161000, C564S164000

Reexamination Certificate

active

07968721

ABSTRACT:
This invention relates to a process for preparing a selective androgen receptor modulator (SARM) compound represented by the structure of formula I:wherein X is O; and T, Z, Y, Q, R and R1are defined herein. The process includes coupling between an amide of formula II and a phenol of formula IIIfollowed by a purification step consisting of precipitating the compound of formula (I) in a mixture of alcohol and water alone.

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