Large scale photolithographic solid phase synthesis of an array

Details Large scale photolithographic solid phase synthesis of an array Large scale photolithographic solid phase synthesis of an array

1992-03-12

1995-04-11

Kepplinger, Esther M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436501, 436527, 436528, 436807, 435 792, 435 794, 435 795, 530333, 530334, 530335, 530337, G01N 33543, C07K 1700

Patent

active

054057833

ABSTRACT:
A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer sequences and locations determined by the order of addition of monomers and the activation patterns formed on the substrate.

REFERENCES:
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4631211 (1986-12-01), Houghten
patent: 5079600 (1992-01-01), Schnur et al.
patent: 5143854 (1992-09-01), Pirrung et al.
Abbott et al, "Manipulation of the Wettability of Surfaces on the 0.1- to 1-Micrometer Scale through Micromachinings and Molecular Self Assembly" Science. vol. 257, 4 Sep. 1992, pp. 1380-1382.
Bhatia et al, "New Approach to Producing Patterned Biomolecular Assemblies", J. Am. Chem. Soc, vol. 114, 4432-4433, 1992.
Flanders et al, "A new interferometric alingment technique" Applied Physics Letters, vol. 31, No. 7 Oct. 1977 pp. 426-428.
Haridasan et al., "Peptide Synthesis Using Photolytically Cleavable 2-Nitrobenzyloxycarbonyl Protecting Group," Proc. Indian Natl. Sci. Acad., Part A (1987) 53:717-728.
Sze/McGillis, VLSI Technology, Chapter 7, pp. 267-301, McGraw-Hill, 1983, "Lithography".
Geysen et al., "Strategies for epitope analysis using peptide synthesis," J. Immunol. Meth. (1987) 102:259-274.
Furka et al., "More Peptides by Less Labor," Abstract No. 288 from Xth International Symposium on Medicinal Chemistry, Budapest, Hungary, Aug. 15-19, 1988.
Kleinfeld et al., "Controlled Outgrowth of Dissociated Neurons on Patterned Substrates", J. of Neuroscience, 8(11);4098-4120, Nov. 1988.

Affiliated with

Also associated with

Rating

Large scale photolithographic solid phase synthesis of an array does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Large scale photolithographic solid phase synthesis of an array , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Large scale photolithographic solid phase synthesis of an array will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1538033