Large scale cultivation of Bordetella pertussis cells for vaccin

Details Large scale cultivation of Bordetella pertussis cells for vaccin Large scale cultivation of Bordetella pertussis cells for vaccin

1982-07-26

1984-01-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

424 92, C12N 120, A61K 3902

Patent

active

044290462

ABSTRACT:
A Bordetella pertussis vaccine is prepared by deep tank cultivation using a seed grown in a biphasic culture system. An anion exchange resin and a Modified Cohen-Wheeler medium used in the process, results in increased antigenicity and a minimization of toxicity in the phase I Bordetella pertussis vaccine.

REFERENCES:
patent: 3577319 (1971-05-01), Nielsen et al.

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