Large-field fluorescence imaging apparatus

Details Large-field fluorescence imaging apparatus Large-field fluorescence imaging apparatus

1998-03-27

2000-10-31

Hannaher, Constantine

Radiant energy

Luminophor irradiation

G01N 2164

Patent

active

061406538

ABSTRACT:
A large-field fluorescence imaging apparatus couples an excitation beam produced by a high-power white light source to a sample with reflective optics to achieve high illumination intensity on the sample. The reflective optics includes a concave mirror which projects the filtered and collimated excitation beam from the white light source onto the sample surface. The concave mirror images a field stop onto the sample surface to define an illumination area which matches the field of view of the imaging optics. The fluorescent light generated in the sample is filtered and imaged on a charge coupled device. The combination of the high illumination intensity and the imaging efficiency allows the imaging apparatus to acquire fluorescent images at an improved rate. A sample-height alignment arrangement using fixed alignment stops allows the sample to be positioned quickly and repeatably in the focal plane of the imaging optics without the need for fine adjustments.

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