Large circular sense molecule array

Details Large circular sense molecule array Large circular sense molecule array

2007-11-20

2007-11-20

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S006120, C435S091400

Reexamination Certificate

active

10627882

ABSTRACT:
Large circular (LC)-sense molecules in an array is disclosed. The LC-sense molecules array is combined with cDNA hybridization to detect differences in expression profile between different cells. LC-sense molecules were purified from nonredundant clones with recombinant phagemid and arrayed onto silanized slide glasses. By hybridization of LC-sense array with Cy3 or Cy5-labelled cDNA preparations at 60° C., 29 up-regulated and 6 down-regulated genes in cancerous liver tissue were detected.

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Drmanac and Drmanac, Processing of cDNA and Genomic Kilobase-Size Clones . . . , BioTechniques, 1994, 17(2): 328-336.

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