Lapachone delivery systems, compositions and uses related...

Details Lapachone delivery systems, compositions and uses related... Lapachone delivery systems, compositions and uses related...

2005-05-10

2005-05-10

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S455000, C549S389000

Reexamination Certificate

active

06890950

ABSTRACT:
In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and using the same. In another part, the present invention includes inclusion complexes of a lapachone or a prodrug thereof and a cyclodextrin, preferably a β-cyclodextrin, such as hydroxypropyl β-cyclodextrin, e.g., to improve the solubility of the lapachone or prodrug thereof.

REFERENCES:
patent: 5100669 (1992-03-01), Hyon et al.
patent: 20030091639 (2003-05-01), Jiang et al.
patent: WO- 94 04145 (1997-03-01), None
patent: WO- 97 07797 (1997-03-01), None
patent: WO- 97 08162 (1997-03-01), None
patent: WO- 97 31936 (1997-09-01), None
patent: WO- 00 61142 (2000-10-01), None
patent: WO- 02 058694 (2002-08-01), None
patent: WO- 03 011224 (2003-02-01), None

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