Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-10-14
2000-02-08
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 13, 435 713, 435 711, 530317, 530326, 530333, A61K 3804, A61K 3812, C07K 1107, C07K 404
Patent
active
060228512
ABSTRACT:
The present invention relates to a novel lantibiotic having the formula NH.sub.2 --R-actagardine, where NH.sub.2 --R is the radical of the amino acid alanine, which is formed by the microorganism Actinoplanes liguriae, DSM 11797 or Actinoplanes garbadiensis, DSM 11796 during fermentation, chemical derivatives of the lantibiotic, a process for its preparation and the use of the lantibiotics as pharmaceuticals.
REFERENCES:
patent: 4022884 (1977-05-01), Parenti et al.
patent: 4684644 (1987-08-01), Malabarba et al.
Jung, Lantibiotics-Ribosomally Synthesized Biologically Active Polypeptides containing Sulfide Bridges and .alpha.,.beta.-Didehydroamino Acids, Chem. Int. Ed. Engl., vol. 30:1051-1068 (1991).
Zimmermann et al., The tetracyclic lantibiotic actagardine .sup.1 H-NMR and .sup.13 C-NMR assignments and revised primary structure, Eur. J. Biochem., vol. 228:786-797 (1995).
Somma et al., Gardimycin, a New Antibiotic Inhibiting Peptidoglycan Synthesis, Antimicrobial Agents and Chemotherapy, vol. 11(3):396-401 (1977).
Malabarba et al., Physico-Chemical and Biological Properties of Actagardine and Some Acid Hydrolysis Products, The Journal of Antibiotics, vol. 38(11):1506-1511 (1985).
Kogler Herbert
Schiell Matthias
Vertesy Laszlo
Wink Joachim
Borin Michael
Hoechst Marion Roussel Deutschland GmbH
Woodward Michael P.
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