Lanthionine antibiotic compositions and methods

Details Lanthionine antibiotic compositions and methods Lanthionine antibiotic compositions and methods

1996-10-23

1999-02-16

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

43525231, 43525232, 43525233, 43525416, 43525421, 4353201, 536 237, C12N 121, C12N 115, C12N 1563, C07H 2104

Patent

active

058720014

ABSTRACT:
Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.

REFERENCES:
Caufield, P.W. et al. "Evidence that mutacin II production is not mediated by a 5.6-kb plasmid in Streptococcus mutans" Plasmid (Sep. 1990), vol. 24, pp. 110-118.
Caufield, P.W. et al. "Use of transposon Tn916 to inactivate and isolate a mutacin-associated gene from Streptococcus mutans" Infection and Immunity (Dec. 1990), vol. 58, No. 12, pp. 4126-4135.

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