Lanthionine antibiotic compositions and methods

Details Lanthionine antibiotic compositions and methods Lanthionine antibiotic compositions and methods

1994-04-20

1997-07-22

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 43524233, 4352534, 536 237, C12N 121, C12N 1563, C07H 2104

Patent

active

056503202

ABSTRACT:
Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.

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