Lanthanide complexes, preparation and uses thereof

Details Lanthanide complexes, preparation and uses thereof Lanthanide complexes, preparation and uses thereof

2010-02-26

2010-11-23

Marcheschi, Michael A (Department: 1797)

Chemistry: analytical and immunological testing

Metal or metal containing

Zn, cd, hg, sc, y, or actinides, or lanthanides

C436S172000, C534S010000, C534S015000, C534S016000, C546S256000

Reexamination Certificate

active

07838299

ABSTRACT:
The invention relates to compounds, to the complexes they form with a lanthanide, and to the use of the complexes for fluorescence marking or NMR imaging. The complex consists of an Ln ion and a ligand R2—C(X—R1)(R3)—NR4R5. R1is a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. R2is an anionic group A2or a C1-C4alkylene or alkenylene group bearing at least one such group A2and optionally comprising at least one hetero atom. R3is H or a C1-C5alkylene or alkenylene group optionally containing at least one hetero atom, and optionally bearing at least one anionic group A3. R4is a substituent with light-absorbing properties that forms chelate rings with Ln. R5is a substituent that forms chelate rings with Ln.

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Weibel, Nicolas, et al., “Engineering of Highly Luminescent Lanthanide Tags Suitable for Protein Labeling and Time-Resolved Luminescence Imaging”,J. Am. Chem. Soc.126(15):4888-4896 (2004).
Search report from PCT/FR2004/001921, dated Feb. 2, 2005.

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