Laminin chains: diagnostic and therapeutic use

Details Laminin chains: diagnostic and therapeutic use Laminin chains: diagnostic and therapeutic use

1997-02-18

2000-11-07

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 723, 4353441, 435960, 436501, 436813, G01N 3353, G01N 33574, G01N 33566, C12N 506

Patent

active

061435058

ABSTRACT:
The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.

REFERENCES:
patent: 5152980 (1992-10-01), Strom et al.
Embase Abstract No: 97163048, 1997.
Snyder et al., ".lambda.gt 11: Gene Isolation with Antibody Probes and Other Applications", in Methods in Enzymology vol. 154 pp 107-128, 1987.
Hao et al., "Differential Expression of Laminin 5 (.alpha.3.beta.3.gamma.2) by Human Malignant and Normal Prostate," Am. J. of Pathol., 149(4):1341-1349, 1996.
Matsui et al, ".gamma..sup.2 Chain of Laminin -5 Is Recognized by Monoclonal Antibody GB3," J. Invest. Dermatol. 105(5):648-652, 1995.
Pyke et al., "The .gamma..sup.2 Chain of Kalinin/Laminin 5 Is Preferentially Expressed in Invading Malignant Cells in Human Cancers," Am. J. Pathol. 145(4):782-791, Oct. 6, 1994.
Pyke et al. "Laminin -5 Is a Marker of Invading Cancer Cells in Some Human Carcinomas . . . ," Cancer Res. 55:4132-4139, 1995.
Verrando et al., "Nicein (BM600) in Junctional Epidermolysis Bullosa: Polyclonal Antibodies Provide New Clues for Pathogenic Role," J. Invest. Dermatol. 101(5):738-743, 1993.
Verrando et al., "Mononclonal Antibody GB3 Defines a Widespread Defect of Several Basement Membranes . . . ", Lab. Invest. 64(1):85-92, 1991.
Wewer et al., "Selective Assembly of Laminin Variants by Human Carcinoma Cells," 71(5): 719-730, Nov. 1994.

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