Laminated microfluidic structures and method for making

Adhesive bonding and miscellaneous chemical manufacture – Methods – Surface bonding and/or assembly therefor

Reexamination Certificate

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C156S272800, C156S273300, C156S273700, C156S285000, C422S502000, C422S503000

Reexamination Certificate

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08057629

ABSTRACT:
A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

REFERENCES:
patent: 2893908 (1959-07-01), Antlfinger
patent: 5882465 (1999-03-01), McReynolds
patent: 7608160 (2009-10-01), Zhou et al.
patent: 2002/0108895 (2002-08-01), Kerfoot
patent: 2003/0232403 (2003-12-01), Kellogg et al.

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