Laminated composite for transdermal administration of fentanyl

Details Laminated composite for transdermal administration of fentanyl Laminated composite for transdermal administration of fentanyl

1992-01-15

1993-02-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 424444, A61F 1302

Patent

active

051869390

ABSTRACT:
A laminated composite for administering fentanyl transdermally that consists of a fentanyl-impermeable occlusive backing layer and an adhesive fentanyl reservoir layer comprising fentanyl dissolved in an amine-resistant polydimethylsiloxane that has a high diffusivity and poor solubility for fentanyl which enables the fentanyl to be released rapidly from the composite over a one day period with little residual fentanyl left in the reservoir thereafter.

REFERENCES:
patent: 4568343 (1986-02-01), Leeps et al.
patent: 4588580 (1986-05-01), Gals et al.

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