Liquid purification or separation – Processes – Separating
Reexamination Certificate
2008-01-15
2008-01-15
Reifsnyder, David A. (Department: 1723)
Liquid purification or separation
Processes
Separating
C210S695000, C366S336000, C422S105000, C422S186100
Reexamination Certificate
active
10248653
ABSTRACT:
A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.
REFERENCES:
patent: 4190535 (1980-02-01), Luderer
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5427663 (1995-06-01), Austin
patent: 5541072 (1996-07-01), Wang et al.
patent: 5622831 (1997-04-01), Liberti et al.
patent: 5639669 (1997-06-01), Ledley
patent: 5707799 (1998-01-01), Hansmann et al.
patent: 5715946 (1998-02-01), Reichenbach
patent: 5750339 (1998-05-01), Smith
patent: 5770029 (1998-06-01), Nelson et al.
patent: 5837115 (1998-11-01), Austin
patent: 5858188 (1999-01-01), Soane et al.
patent: 5866345 (1999-02-01), Wilding et al.
patent: 5928880 (1999-07-01), Wilding et al.
patent: 5952173 (1999-09-01), Hansmann et al.
patent: 6007690 (1999-12-01), Nelson
patent: 6054034 (2000-04-01), Soane et al.
patent: 6074827 (2000-06-01), Nelson
patent: 6156270 (2000-12-01), Buechler
patent: 6197523 (2001-03-01), Rimm et al.
patent: 6221671 (2001-04-01), Groner et al.
patent: 6241894 (2001-06-01), Briggs et al.
patent: 6251691 (2001-06-01), Seul
patent: 6256093 (2001-07-01), Johnson
patent: 6265229 (2001-07-01), Fodstad et al.
patent: 6315940 (2001-11-01), Nisch et al.
patent: 6344326 (2002-02-01), Nelson
patent: 6361958 (2002-03-01), Shieh
patent: 6368871 (2002-04-01), Christel et al.
patent: 6387290 (2002-05-01), Brody et al.
patent: 6432630 (2002-08-01), Blankenstein
patent: 6454938 (2002-09-01), Moon et al.
patent: 6465225 (2002-10-01), Fuhr et al.
patent: 6540895 (2003-04-01), Spence et al.
patent: 6613525 (2003-09-01), Nelson et al.
patent: 6632619 (2003-10-01), Harrison et al.
patent: 6635163 (2003-10-01), Han et al.
patent: 6664104 (2003-11-01), Pourahmadi et al.
patent: 6685841 (2004-02-01), Lopez et al.
patent: 6746503 (2004-06-01), Benett et al.
patent: 6762059 (2004-07-01), Chan et al.
patent: 6783647 (2004-08-01), Culbertson et al.
patent: 6815664 (2004-11-01), Wang et al.
patent: 6878271 (2005-04-01), Gilbert et al.
patent: 6881315 (2005-04-01), Iida et al.
patent: 6893881 (2005-05-01), Fodstad et al.
patent: 6913697 (2005-07-01), Lopez et al.
patent: 6958245 (2005-10-01), Seul et al.
patent: 2001/0036672 (2001-11-01), Anderson et al.
patent: 2002/0005354 (2002-01-01), Spence et al.
patent: 2002/0058332 (2002-05-01), Quake et al.
patent: 2002/0090741 (2002-07-01), Jurgensen et al.
patent: 2002/0108859 (2002-08-01), Wang et al.
patent: 2002/0113204 (2002-08-01), Wang et al.
patent: 2002/0115163 (2002-08-01), Wang et al.
patent: 2002/0115164 (2002-08-01), Wang et al.
patent: 2002/0123078 (2002-09-01), Seul et al.
patent: 2002/0123112 (2002-09-01), Wang et al.
patent: 2002/0132315 (2002-09-01), Wang et al.
patent: 2002/0132316 (2002-09-01), Wang et al.
patent: 2002/0172987 (2002-11-01), Terstappen et al.
patent: 2003/0072682 (2003-04-01), Kikinis
patent: 2003/0077292 (2003-04-01), Hanash et al.
patent: 2004/0018116 (2004-01-01), Desmond et al.
patent: 2004/0072278 (2004-04-01), Chou et al.
patent: 2004/0121343 (2004-06-01), Buechler et al.
patent: 2004/0144651 (2004-07-01), Huang et al.
patent: 2005/0049793 (2005-03-01), Paterlini-Brechot
patent: 2005/0164158 (2005-07-01), Wang et al.
patent: 2006/0060767 (2006-03-01), Wang et al.
patent: 19712309 (1998-05-01), None
patent: 1221342 (2002-07-01), None
patent: 1412729 (2003-01-01), None
patent: 1438398 (2003-05-01), None
patent: 1338894 (2003-08-01), None
patent: 1485713 (2003-09-01), None
patent: 1499706 (2003-10-01), None
patent: 1539350 (2004-01-01), None
patent: 1529211 (2004-02-01), None
patent: 1542802 (2004-03-01), None
patent: 1418003 (2004-05-01), None
patent: 1462800 (2004-09-01), None
patent: WO94/29707 (1994-12-01), None
patent: WO-98/10267 (1998-03-01), None
patent: WO99/44064 (1999-09-01), None
patent: WO 00/00816 (2000-01-01), None
patent: WO 02/12896 (2002-02-01), None
patent: WO 02/28523 (2002-04-01), None
patent: WO 02/30562 (2002-04-01), None
patent: WO 02/44689 (2002-06-01), None
patent: WO 03/031938 (2003-04-01), None
patent: WO 2004/029221 (2004-04-01), None
patent: WO 2004/037374 (2004-05-01), None
patent: WO 2004/056978 (2004-07-01), None
S. Takayama, J. Cooper McDonald, E. Ostuni, M.N. Liang, P.J.A. Kenis, R.F. Ismagilov and G.M. Whitesides, “Patterning Cells and Their Environments Using Multiple Laminar Fluid Flows in Capillary Networks”,Proceedings of the National Academy of Sciences of the United States of America, May 11, 1999, pp. 5545-5548, 96-#10, National Academy of Sciences, USA.
P.J.A. Kenis, R.F. Ismagilov and G.M. Whitesides, “Microfabrication Inside Capillaries Using Multiphase Laminar Flow Patterning”,Science, Jul. 2, 1999, pp. 83-85, 285, American Association for the Advancement of Science, USA.
N.L. Jeon, S.K.W. Dertinger, D.T. Chiu, I.S. Choi, A.D. Stroock and G.M. Whitesides, “Generation of Solution and Surface Gradients Using Microfluidic Systems”,Langmuir, 2000, pp. 8311-8316, 16-#22, American Chemical Society, USA.
B.H Weigl and P. Yager, “Microfluidic Diffusion-Based Separation and Detection”,Science, Jan. 15, 1999, pp. 346-347, 283-#5400, American Association for the Advancement of Science, USA.
P.C H. Li and D.J. Harrison, “Transport, Manipulation, and Reaction of Biological Cells On-Chip Using Electrokinetic Effects”,Analytical Chemistry, Apr. 15, 1997, pp. 1564-1568, 69-#8, American Chemical Society, USA.
S. Fiedler, S.G. Shirley, T. Schnelle and G. Fuhr, “Dielectrophoretic Sorting of Particles and Cells in a Microsystem”,Analytical Chemistry, May 1, 1998, pp. 1909-1915, 70-#9, American Chemical Society, USA.
A.Y. Fu, C. Spence, A. Scherer, F.H. Arnold and S.R. Quake, “A Microfabricated Flourescence-Activated Cell Sorter”,Nature Biotechnology, Nov. 1999, pp. 1109-1111, 17, Nature America Inc., USA.
Y. Huang, K.L. Ewalt, M. Tirado, R. Haigis, A. Forster, D. Ackley, M.J. Heller, J.P. O'Connell and M. Krihak, “Electric Manipulation of Bioparticles and Macromolecules on Microfabricated Electrodes”,Analytical Chemistry, Apr. 1, 2001, pp. 1549-1559, 73-#7, American Chemical Society, USA.
S. Takayama, E. Ostuni, P. Leduc, K. Naruse, D.E. Ingber and G. M. Whitesides, “Subcellular Position of Small Molecules”,Nature, Jun. 28, 2001, p. 1016, 411, Nature Publishing Group (USA), a division of Macmillan Publishers Ltd., United Kingdom.
G. Fuhr and S.G. Shirley, “Biological Application of Microstructures”,Topics in Current Chemistry, 1997, pp. 83-116, 194, Springer-Verlag, Germany.
A.E. Kamholz, B.H. Weigl, B.A. Finlayson and P. Yager, “Quantitative Analysis of Molecular Interaction in a Microfluidic Channel: the T-Sensor”,Analytical Chemistry, Dec. 1, 1999, pp. 5340-5347, 71-#23, American Chemical Society, USA.
M. Eigen and R. Rigler, “Sorting Single Molecules: Application to Diagnostics and Evolutionary Biotechnology”,Proceedings of the National Academy of Sciences of the United States of America, Jun. 1994, pp. 5740-5747, 91, National Academy of Sciences, USA.
C.F. Chou, O. Bakajin, S.W. P. Turner, T. Duke, S.S. Chan, E.C. Cox, H.G. Craighead and R.H. Austin, “Sorting by Diffusion: an Asymmetric Obstacle Course for Continuous Molecular Separation”,Proceedings of the National Academy of Sciences of the United Sates of America, Nov. 23, 1999, pp. 13762-13765, 96-#24, National Academy of
Marr David W. M.
Oakey John
Colorado School of Mines
Reifsnyder David A.
Sheridan & Ross P.C.
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