Lamellar vesicles formed of cholesterol derivatives

Details Lamellar vesicles formed of cholesterol derivatives Lamellar vesicles formed of cholesterol derivatives

1988-10-17

1990-11-20

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514772, A61K 3722, A61K 4700

Patent

active

049718037

ABSTRACT:
Closed, unilamellar vesicles are spontaneously formed by adding a cholesteryl compound substituted with a hydroxyl terminated polyethylene oxide containing 1 to 4 ethylene oxide groups to a polar liquid. Multilamellar vesicles are formed by sonicating a cholesteryl compound containing polyethylene oxide or polyamine side-chains. The vesicles can be utilized to dispense polar, non-polar or ampholphilic compounds.

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