Lamellar gels and methods for making and regulating

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S401000

Reexamination Certificate

active

06899895

ABSTRACT:
The invention provides novel compositions involving lamellar gels and methods for making them. These compositions and methods of the invention are significant improvements in the field of gels, macromolecular targeting and macromolecular delivery to various biological systems.

REFERENCES:
patent: 4774085 (1988-09-01), Fidler
patent: 5013556 (1991-05-01), Woodle
patent: 5288499 (1994-02-01), Janoff et al.
patent: 5374715 (1994-12-01), Kanno
patent: 5741513 (1998-04-01), Ghyczy
patent: 5882679 (1999-03-01), Needham
Behr, Jean Paul, “Gene Transfer with Synthetic Cationic Amphiphiles: Prospects for Gene Therapy,” Bioconjugate Chem, 5:382-389. 1994 (Exhibit 3).
Radler, Joachim et al., “Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes,”Science, 275:810-814. Feb 7, 1997 (Exhibit 4).
Felgner, P. L. and G. Rhodes, “Gene Therapeutics,”Nature, 349:351-352. Jan. 24, 1991 (Exhibit 5).
Felgner, P. L. et al., “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure,”Proc. Natl. Acad. Sci. USA, 84:7413-7417. Nov. 1987 (Exhibit 6).
Remy, Jean-Serge et al., “Targeted gene transfer into hepatoma cells eith lipopolyamine-condensed DNA particles presenting galactose ligands: A stage toward artificial viruses,”Proc. Natl. Acad. Sci. USA, 92:1744-1748. Feb. 1995 (Exhibit 7).
Zhu, Ning et al., “Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice,”Science, 261:209-211. Jul. 9, 1993 (Exhibit 8).
Remy, Jean-Serge et al., “Gene Transfer with a Series of Lipophilic DNA-Binding Molecules,”Bioconjugate Chem., 5:647-654. 1994 (Exhibit 9).
Felgner, Jiin H. et al., “Enhanced Gene Delivery and Mechanism Studies with a Novel Series of Cationic Lipid Formulations,”The JOurnal of Biological Chemistry, 269(4):2550-2561. 1994 (Exhibit 10).
Farhood, Hassan et al., “The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer,”Biochemica et Biophysica Acta, 1235:289-295. 1995 (Exhibit 11).
Hui, Sek Wen et al., “The Role of Helper Lipids in Cationic Liposome-Mediated Gene Transfer,”Biophysical Journal, 71:590-599. Aug. 1996 (Exhibit 12).
Chiang, Ming-Yi et al., “Antisense Oligonucleotides Inhibit Intracellular Adhesion Molecule 1 Expression by Two Distinct Mechanism,”The Journal of Biological Chemistry, 266(7):18162-18171. Sep. 25, 1991 (Exhibit 13).
Lappalainen, Katriina et al., “Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells,”Biochemica et Biophysica Acta, 1196:201-208. 1994 (Exhibit 14).
Seddon, John M., “Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transition of lipids,”Biochemica et Biophysica Acta, 1031:1-69. 1990 (Exhibit 15).
Boltenhagen, Ph. et al., “Focal conic domains with positive Gaussian curvature and saddle-splay rigidity of smectic Lαphases,”Physical Review A, 46(4):R1743-R1746. Aug. 15, 1992 (Exhibit 16).
Gruner, Sol M., “Stability of Lyotropic Phases with Curved Interfaces,”J. Phys. Chem., 93:7562-7570. 1989 (Exhibit 17).
Antonietti, Markus et al., “Polyelectrolyte-Surfactant Complexes: A New Type of Solid, Mesomorphous Material,”Macromolecules, 27:6007-6011. 1994 (Exhibit 18).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Lamellar gels and methods for making and regulating does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lamellar gels and methods for making and regulating, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lamellar gels and methods for making and regulating will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3427337

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.