Lag 1:gene for increasing the longevity of eukaryotes

Details Lag 1:gene for increasing the longevity of eukaryotes Lag 1:gene for increasing the longevity of eukaryotes

1994-11-08

1998-10-06

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 2432, 435 691, 4351723, 435 6, 435 5, 4352542, 4352543, 435 912, 435 911, 4352402, C07H 2102, C07H 2104, C12Q 168, C12P 1934

Patent

active

058177825

ABSTRACT:
The present invention provides a unique eukaryotic gene, called LAG1, which controls the longevity of eukaryotic cells. According to the present invention, overexpression of LAG1 in older cells has a rejuvenating effect which not only increases cellular life span but also reproductive capacity and cellular tolerance to stress factors such as starvation and low pH. Moreover, the present invention identifies two domains in LAG1 one having a life span limiting function and the other a life span extending function. Hence, according to the present invention, the longevity and tolerance to stress of cells is increased when provided with the wild type polypeptide or mutant LAG1 polypeptides which, for example, lack the "life span limiting domain."

REFERENCES:
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D/mello et al. Cloning and Characterization of LAG1, a Longevity-assurance Gene in Yeast.The Journal of Biological Chemistry 269: 15451-15459, 1994.
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