Lactose spherical particles and process for their production

Details Lactose spherical particles and process for their production Lactose spherical particles and process for their production

1997-01-24

1998-08-11

Dudash, Diana

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

427 215, 427213, 427214, 427240, 427242, 427378, B05D 138, B05D 140, B05D 102

Patent

active

057925070

ABSTRACT:
To provide spherical particles made substantially from lactose and having high surface smoothness with low abrasiveness, and a process for their production.
A process for producing spherical particles containing at least 95 wt % lactose, characterized by comprising a step of producing lactose spherical particles by charging crystalline lactose and/or lactose granules onto a rotary disk in the treatment vessel of a centrifugal tumbling apparatus, dispersing powdered lactose to the lactose granules and/or crystalline lactose as the rotary disk is rotated while providing slit air into the vessel, while also spraying water, an aqueous lactose solution or a dilute aqueous solution of a water-soluble polymer, and a fixation treatment step of drying the obtained spherical particles in a fluidized bed apparatus while spraying an aqueous lactose solution and/or a dilute solution of a water-soluble polymer.

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patent: 5618562 (1997-04-01), Saito et al.

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