Lactones with antioxidising and hypolipidaemic activity useful i

Details Lactones with antioxidising and hypolipidaemic activity useful i Lactones with antioxidising and hypolipidaemic activity useful i

1995-11-13

1997-03-04

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562464, 562471, 560254, C07D32100, C07C 5990

Patent

active

056080840

ABSTRACT:
Lactones of formula ##STR1## and their pharmacologically acceptable salts endowed with antioxiding and hypolipidaemic properties and that show the capability to prevent and/or to delay the oxidative modification of the lipoproteins by competing with the chain of propagation of the lipidic peroxidation by means of an effective scavenging of the peroxylic radicals. The compounds object of the present invention are useful in the treatment of the atherosclerosis and of many correlated vascular pathologies, like ischaemic cardiopathies (angina pectoris and myocardial infarction), cerebral thrombosis and peripheral arteriopathies, because the high plasma levels of lipids and the oxidative modifications of the low density lipoproteins (LDL) represent crucial events in the pathogenesis of the atherosclerosis.

REFERENCES:
patent: 5196447 (1993-03-01), Pettit et al.

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