Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-11-16
1986-04-22
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549264, 549265, C07D49520, C07D49522, A01N 4322, A61K 31365
Patent
active
045843147
ABSTRACT:
The compound of formula I ##STR1## wherein R.sub.2 is methyl, ethyl, isopropyl or sec-butyl, can be prepared by selective chlorination of an appropriate milbemycin derivative either with hypochlorous acid (HOCl) or sulfuryl chloride (SO.sub.2 Cl.sub.2) in the temperature range from -10.degree. to +60.degree. C. It is employed as pesticide for controlling Arthropode species such as injurious insects or ecto- or endoparasites of animals, and is applied in the form of compositions. This compound is also used as intermediate for obtaining further milbemycin derivatives.
REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4156720 (1979-05-01), Fisher et al.
Hedge et al., Tetrahedron Letters, vol. 21, pp. 441-444, (1980), "The Reaction of Hypochlorous Acid with Olefins, Convenient Synthesis . . . ".
Hedge et al., Tetrahedron Letters, vol. 22, pp. 5019-5022, No. 5, (1981), "Hypochlorous Acid, Reaction with Conjugated Ketones . . . ".
Ciba-Geigy Corporation
Dinner Dara
Hollrah Glennon H.
McC. Roberts Edward
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