Lactol derivatives, their production and use

Details Lactol derivatives, their production and use Lactol derivatives, their production and use

1994-09-02

1996-03-05

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 514419, 514459, 514461, 546164, 546283, 546268, 546275, 548440, 548441, 548444, 548467, 549419, 549475, A61K 3144, A61K 3140, A61K 3135

Patent

active

054968348

ABSTRACT:
The present invention provides novel compound of the formulas (Ia) or (I): ##STR1## wherein Q is one or two amino acid residues which may be substituted; R.sup.3 is a carboxyl group which may be esterified or an acyl group; A is an alkylene group; B is hydrogen or an alkyl group which may be substituted or an acyl group; or a salt thereof; ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different and each is hydrogen or a hydrocarbon residue which may be substituted; R.sup.3, A and B have the same definitions as those shown above; m and n each is 0 or 1; provided that where both m and n are both equal to 0, R.sup.3 is a carboxyl group which may be esterified or an acyl group having not less than 7 carbon atoms; or a salt thereof.
The compound (Ia) or (I) shows cathepsin L inhibitory and bone resorption inhibitory activities and are useful as a prophylactic/therapeutic agent for osteoporosis.

REFERENCES:
Alves, R. J., et al., J. Carbohydrate Chemistry 10(6):1049-1057 (1991).
Can. J. of Chemistry, 60, 558 (1982).
Can. J. of Chemistry, 56, 119 (1978).
Tet. Lett., 30, 5421 (1989).
Chem. Pharm. Bull., 16, 1881 (1968).
Eur. J. Med. Chem. 12, 317 (1977).
Biochem. Biophys. Res. Comm., 49, 343 (1972).
JO 2304-085-A (May 18, 1989).

Affiliated with

Also associated with

Rating

Lactol derivatives, their production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lactol derivatives, their production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lactol derivatives, their production and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1413147