Lactoferrin in the reduction of circulating cholesterol,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S002600, C514S021800, C530S350000, C530S300000, C435S007100

Reexamination Certificate

active

07026295

ABSTRACT:
The present invention relates to methods of using lactoferrin (LF) to reduce circulating levels of cholesterol and vascular inflammation, in order to treat, prevent or reduce the incidence of atherosclerosis and cardiovascular disease.

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patent: 2003/0060425 (2003-03-01), Ahlem et al.
patent: WO-0241912 (2002-05-01), None
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Croy et al, “All three LDL Receptor Homology Regions of the LDL Receptor-related Protein Binf Multiple Ligands,” Biochemistry Nov. 11, 2003; 42(44): 13049-13057.
Huettinger, M. et al, “The LDL-receptor Family: Lactoferrin and Lipid Metabolism,” Adv Exp. Med Biol. 1998; 443: 107-11.
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van Dijk MC et al, “Recognition of Chylomicron Remnants and Beta-Migrating very-low Density Lipoproteins by the Remnant Receptor of Parenchymal Liver Cells is Distinct from the Liver Alpha 2-Macroglobulin Recognition Site,” Biochem J. 1991 No. 1; 279(Pt. 3): 863-70.
Benezra, M. et al, “A Synthetic Heparin-Mimicking Polyanionic Compound Binds to the LDL Receptor-related Protein and inhibits Vascular Smooth Muscle Cell Proliferation,” J. Cell Biochem 2001; 81(1): 114-27.
Hayashida et al, “Bovine Lactoferrin has a Nitric Oxide-dependent Hypotensive Effect in Rats,” Am J Physiol Regul Integr Comp Physiol. Feb. 2004; 286(2): R359-65.
Llirbat et al, “Normal and Inhibited Cholesterol Synthesis in the Cultured Rat Embryo,” Journal of Lipid Research vol. 38, pp. 22-34 (1997).

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