Lactic acid bacteria producing lantibiotics similar to nisin A

Details Lactic acid bacteria producing lantibiotics similar to nisin A Lactic acid bacteria producing lantibiotics similar to nisin A

1996-09-19

1999-07-27

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Plant cell or cell line, per se ; composition thereof;...

Culture, maintenance, or preservation techniques, per se

4352521, 4352534, C12N 1587, C12N 121

Patent

active

059289465

ABSTRACT:
The invention relates primarily to a number of lantibiotics similar to nisin A, which differ from nisin A by substitution, deletion or insertion of one or more amino acids, such as, in particular, the naturally occurring analogue of nisin A, termed nisin Z, which has the structure given above. Lantibiotics of this type are particularly suitable for preserving foodstuffs for humans and animals. This preservation takes place by the use of these lantibiotics themselves or of microorganisms producing these lantibiotics, in particular lactic acid bacteria, in the preparation or storage of foodstuffs.

REFERENCES:
patent: 5137297 (1992-08-01), Vedamuthu et al.
patent: 5231165 (1993-07-01), Vedamuthu et al.
N. Schnell et al., "Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings", Nature, vol. 333, May 19, 1988, London, England, pp. 276-278.
W. Chan et al., "Isolation and characterization of two degradation products derived from the peptide antibiotic nisin", FEBS Letters, vol. 252, No. 1,2, Jul. 1989, pp. 29-36.
E. Broadbent et al., "Generic construction of nisin producing L. lactis subsp. cremoris and analysis of a rapid method for conjugation", Applied and Environmental Microbiology, vol. 57, No. 2, Feb. 1991, p. 517.
J. Mulders, "Identification and characterization of the lantibiotic nisin Z, a natural nisin variant", Eur. J. Biochem, vol. 201, No. 3, Nov. 1, 1991, pp. 581-584.
Rauch, P.J.G, et al., (1990) Nucl. Acids Res. 18(14) 4253-5254.

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