Lactic acid bacteria for the treatment and/or prophylaxis of...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales

Reexamination Certificate

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Details

C424S093450, C424S408000, C424S439000, C424S450000

Reexamination Certificate

active

06905679

ABSTRACT:
The present invention relates to the use of a supernatant of lactic acid bacteria or of Bifidobacteria capable of preventing colonization of intestinal cells byGiardia intestinalis, for the preparation of an ingestable carrier for the treatment and/or prophylaxis of disorders associated with the colonization of the gut byGiardia intestinalis. The present invention also pertains to specific strains of Bifidobacterium having the above traits and to the ingestable carrier, such as a food or pharmaceutical composition containing such supernatant or the microorganisms.

REFERENCES:
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patent: WO 96/29083 (1996-09-01), None
patent: WO 97/35596 (1997-10-01), None
patent: WO 01/30365 (2001-05-01), None
Thompson et al. article entitled “Nomenclature and Genetic Groupings ofGiardiaInfecting Mammals”Parasitology Today, vol. 16, No. 5, 2000, pp. 210-213.
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Buret et al., “Pathophysiology of Small Intestinal Malabsorption in Gerbils Infected WithGiardia Iamblia,” Gastroenterology 103, 1992, pp. 506-513.
Roberts-Thomson, et al., “Giardiasis in the Mouse: An Animal Model” Gastroenterology 71, 1976, pp. 57-61.
Aley et al., “Specialized Surface Adaptations ofGiardia lamblia” Infectious Agents and Disease, 4, 1995, pp. 161-166.
Muller et al., “Serological Analysis of Antigenic Heterogeneity ofGiardia lambliaVariant Surface Proteins” Infection and Immunity, 64, 1996, pp. 1385-1390.
Nash et al., “Giardia lamblia:Identification and Characterization of a Variant-Specific Surface Protein Gene Family” J. Euk. Microbiol., 42, 1995, pp. 604-609.
Gillin et al., “Cell Biology of the Primitive EukaryoteGiardia Lamblia” Annu. Rev. Microbiol. 50, 1996, pp. 679-705.
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