Lactams substituted by cyclic succinates as inhibitors of...

Details Lactams substituted by cyclic succinates as inhibitors of... Lactams substituted by cyclic succinates as inhibitors of...

2007-10-31

2008-11-25

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07456278

ABSTRACT:
This invention relates to novel lactams having the Formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

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