Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-03-10
2008-03-11
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S527000
Reexamination Certificate
active
07342007
ABSTRACT:
This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease
REFERENCES:
patent: 5936065 (1999-08-01), Arrhenius et al.
patent: 2006/0089346 (2006-04-01), Becker et al.
patent: WO 90/09162 (1990-08-01), None
patent: WO 97/24339 (1997-07-01), None
patent: WO 98/17680 (1998-04-01), None
patent: WO 98/28268 (1998-07-01), None
patent: WO 99/67221 (1999-12-01), None
patent: WO 00/02903 (2000-01-01), None
patent: WO 00/07995 (2000-02-01), None
patent: WO 01/68655 (2001-09-01), None
patent: WO 01/72324 (2001-10-01), None
patent: 2004031154 (2004-04-01), None
Petersen et al., “Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology,”Neurology(2001) 56(9):1133-1142.
Ritchie et al., “Classification criteria for mild cognitive impairment: a population-based validation study,”Neurology(2001) 56(1):37-42.
Nitsch “Immunotherapy of Alzheimer Disease,” Alzheimer Dis Assoc Disord (2004) 18(4):185-189.
Marjaux et al., “γ-Secretase inhibitors: still in the running as Alzheimer's therapeutics,” Drug Discovery Today: Therapeutic Strategies (2004) 1(1):1-6.
Heinrikson “Secretases,” Biological Chemistry Chapter 4, pp. 7-10, Elsevier Ltd., Oxford, UK (2004).
Herzog Keith John
Jacobs Robert
Kang Jianxing
Simpson Thomas Richard
Woods James M
AstraZeneca AB
Kifle Bruck
Pepper Hamilton LLP
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