Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-07
2005-06-07
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S234200, C514S234800, C514S256000, C540S524000, C544S122000, C544S328000
Reexamination Certificate
active
06903089
ABSTRACT:
The invention relates to novel pyrazolopyridine derivatives of formula (I)wherein R1represents NH2or NHCO-C1-6-alkyl, and R2represents a radical of formula R3NCOR4which is bonded to the remainder of the molecule by means of the nitrogen atom, R3and R4forming, together with the amide group to which they are bonded, a five to seven-membered heterocycle which may be saturated or partially unsaturated, may optionally contain a further heteroatom selected from the group N, O, and S and may comprise between one and five other substituents chosen from oxo, C1-6alkyl, hydroxyl, hydroxy-C1-6-alkyl, halogen, or may be fused to a C6-10ARYL ring or a C3-8cycloalkyl ring in which optionally two carbon atoms are bonded to each other by means of an oxygen atom. The invention also relates to salts, isomers and hydrates of the derivatives in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system. Processes for preparing these materials, and pharmaceutical compositions containing them are also disclosed and claimed.
REFERENCES:
patent: 6166027 (2000-12-01), Straub et al.
patent: 6180656 (2001-01-01), Furstner et al.
patent: 6451805 (2002-09-01), Straub et al.
patent: 9816223 (1998-04-01), None
patent: 9816507 (1998-04-01), None
patent: 9823619 (1998-06-01), None
patent: 0006567 (2000-02-01), None
patent: 0006568 (2000-02-01), None
patent: 0006569 (2000-02-01), None
patent: 0021954 (2000-04-01), None
Fisker et al., PubMed Abstract (J Endocrinol Invest. 22(5 Suppl):89-93), 1999.
Layzer, Degenerative Diseases of the Nervous Sytem, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-7, 1996.
Damasio, Alzheimer's Disease and Related Dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-6, 1996.
Ko., et al., Blood,84, 4226-4233 (1994).
Mulsch, et al., Br. J. Pharmacol.120, 681-689 (1997).
Pettibone, et al., Eur. J. Pharmacol.116, 307-312 (1985).
Yu, et al., Brit. J. Pharmacol.114, 1587-1594 (1995).
Alonso-Alija Cristina
Dembowsky Klaus
Feurer Achim
Flubacher Dietmar
Lang Dieter
Bayer Aktiengesellschaft
Rao Deepak
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