Lactam inhibitors of Hepatitis C virus NS3 protease

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S330000, C514S018700, C514S019300

Reexamination Certificate

active

07122627

ABSTRACT:
The present invention relates to lactams of Formula (I):or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

REFERENCES:
patent: 2 758 329 (1998-07-01), None
patent: WO 93/21213 (1993-10-01), None
patent: WO 93/21214 (1993-10-01), None
patent: WO 95/09634 (1995-04-01), None
patent: WO 97/43310 (1997-11-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/22496 (1998-05-01), None
patent: WO 98/24806 (1998-06-01), None
patent: WO 98/46630 (1998-10-01), None
patent: WO 99/07733 (1999-02-01), None
patent: WO 99/07734 (1999-02-01), None
patent: WO 01/07407 (2001-02-01), None
Ingallinella et al. (1998) Biochemistry 37:8906-8914.
Matteson et al. (1983) Organometallics 2:1529-1535.
Matteson et al. (1982) Organometallics 1:280-288.
Steinkühler et al. (1998) Biochemistry 37:8899-8905.
Poynard et al. (1998) Lancet 352:1426-1432.
Llinas-Brunet et al. (1998) Bioorg. Med. Chem. Lett. 8:1713-1718.
Roberts and Vellaccio (1983) The Peptides 5:342-429.
Chou and Talalay (1984) Adv. Enzyme Regul. 2:27-55.
Carpino et al. (1984) J. Chem. Soc., Chem. Comm. 201-203.
Myers et al. (1997) J. Am. Chem. Soc. 119:656-673.
D.A. Evans et al. (1990) J. Am. Chem. Soc. 112:4011.
P.D. Edwards et al. (1994) Medicinal Res. Reviews 14:127-194.
D.S. Matteson et al. (1984) Organometallics 3:1284-1288.
I. Ugi et al. (1965) Angew. Chem., Intl. Ed. Eng. 4:472.
D. Hoppe (1974) Angew. Chem., Intl. Ed. Eng. 13:789-804.
R. Roeske (1963) J. Org. Chem. 28:1251-1253.
Albericio et al. (1998) J. Org. Chem. 63:9678-9683.
H. Wenschuh et al. (1996) Tetrahedron Lett. 37:5483-5486.
S.J. Miller et al. (1996) J. Am. Chem. Soc. 118:9606.
G.W. Gribble et al. (1996) J. Heterocyclic Chem. 33:719-726.
Matteson and Majumdar (1979) J. Organometallic Chem. 170:259-264.
Sadhu and Matteson (1985) Organometallics 4:1687-1689.
Steven D. Young et al. (1995) Antimicrobial Agents and Chemotherapy 2602-2605.
Andrew S. Thompson et al. (1995) Tet. Lett., 36:8937-8940.
M.W. Anderson et al. (1989) Chem. Ber., 122:1777-1782.
C. Steinkühler et al. (1996) Journal of Virology 70:6694-6670.
C. Steinkühler et al. (1996) Journal of Biological Chemistry 271:6367-6373.
Taliani et al. (1996) Anal. Biochem. 240:60-67.
Bleth (1996) Methods Enzymol. 248:58-85.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Lactam inhibitors of Hepatitis C virus NS3 protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lactam inhibitors of Hepatitis C virus NS3 protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lactam inhibitors of Hepatitis C virus NS3 protease will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3654493

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.