Lactam glycogen phosphorylase inhibitors and method of use

Details Lactam glycogen phosphorylase inhibitors and method of use Lactam glycogen phosphorylase inhibitors and method of use

2006-06-06

2006-06-06

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S122000, C546S153000, C514S300000, C514S301000, C514S312000

Reexamination Certificate

active

07057046

ABSTRACT:
A compound of formula IwhereinW is a bicyclic hetroaryl of the structureX is —O—, —S—, —SO2—, —CHR5—, —CHR5O—, —CHR5S—, —CHR5SO2—, —CHR5CO— or —CH2CHR5—;Y is a bond or —CHR6—;Z is an aryl or heteroaryl group of the following structure:A is —CH— or —N—;B is —O— or —S—; andR1, R2, R3, R4, R5, R6, R7and R8are as described herein.Further provided is a method for treating diabetes and related diseases employing a glycogen phosphorylase inhibiting amount of the above compound, either alone or in combination with another therapeutic agent.

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