Lactam derivatives as inhibitors of matrix...

Details Lactam derivatives as inhibitors of matrix... Lactam derivatives as inhibitors of matrix...

2006-10-17

2006-10-17

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S013400, C514S314000, 56, 56, 56

Reexamination Certificate

active

07122560

ABSTRACT:
The present invention provides compounds of Formula (I):or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, R1, R2, U, X, Y, Z, Ua, Xa, Ya, and Zaare defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP), and/or TNF-α converting enzyme (TACE), or a combination thereof.

REFERENCES:
patent: 6495548 (2002-12-01), Duan
patent: 6825215 (2004-11-01), Chen et al.
patent: WO 97/32846 (1997-09-01), None

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