Lactam derivatives and their use as hypotensive agents

Details Lactam derivatives and their use as hypotensive agents Lactam derivatives and their use as hypotensive agents

1986-10-09

1988-03-29

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514183, 514321, 540527, 540524, 540463, 546223, C07D22502, C07D22310, A61K 3155, A61K 31395

Patent

active

047344105

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein R.sup.1 and R.sup.3 are organic groups, A is a direct bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CO--CH.sub.2, --O--CH.sub.2 -- or --S--CH.sub.2 --, B is lower alkylene and n is 1-3) are valuable hypotensive agents which may be prepared by a condensation reaction of the corresponding compound having an amino group at the 3-position.

REFERENCES:
patent: 4587050 (1986-05-01), Harris et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4680392 (1987-07-01), Harris et al.
patent: 4699905 (1987-11-01), Yanagisawa et al.
Eugene D. Thorsett et al., Peptides Structure and Function, American Peptide Symposium (8th: 1983: University of Arizona), pp. 556-558.

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