Lactam derivatives

Details Lactam derivatives Lactam derivatives

1991-01-11

1993-03-02

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 540463, 540524, 540525, 540527, C07D22502, C07D22310, A61K 3155, A61K 31395

Patent

active

051909375

ABSTRACT:
Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: ##STR1## in which, R.sub.1 is --OH; alkoxy; aryloxy or aralkyloxy in each of which the aryl group is optionally substituted; --NR.sub.6 R.sub.7, where each of R.sub.6 and R.sub.7 is independently hydrogen or alkyl, or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring; or a group:

REFERENCES:
patent: 4587050 (1986-05-01), Harris et al.
patent: 4734410 (1988-03-01), Yanagisawa et al.
patent: 4831135 (1990-05-01), Crews
patent: 4908445 (1990-03-01), Rinehart

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