Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-04-26
1991-01-15
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540521, 546 86, 546 89, 546 80, 546 92, 514291, 514292, C07D48704, C07D47104, A61K 3155, A61K 31445
Patent
active
049854224
ABSTRACT:
Compounds which are potent and selective antagonists of the effect of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, anxiety, and nausea and vomiting, of the general formula (I) ##STR1## wherein Im represents an imidazolyl group of the formula (a), (b) or (c): ##STR2## one of the groups represented by R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenyl C.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;
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March, J., Advanced Organic Chemistry, McGraw Hill, New York, NY 1968, p. 331.
Beswick Paul J.
Coates Ian H.
North Peter C.
Oxford Alexander W.
Glaxo Group Limited
Lee Mary C.
Miltenberger Lenora
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