Lactam compounds which are useful in the treatment of asthma

Details Lactam compounds which are useful in the treatment of asthma Lactam compounds which are useful in the treatment of asthma

1996-04-08

1997-10-14

Northington Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514826, 546188, 546193, 546194, 546203, C07D41312, A61K 31445

Patent

active

056773170

ABSTRACT:
Compounds of formula I ##STR1## wherein J, B, L, X, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
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patent: 5300648 (1994-04-01), Emonds-Alt et al.
patent: 5340822 (1994-08-01), Emonds-Alt et al.
patent: 5411971 (1995-05-01), Edmonds-Alt et al.
patent: 5434158 (1995-07-01), Shah
A. Graham et al., "Isolation and Characterisation of the Human Lung NK-2 Receptor Gene Using Rapid Amplification of cDNA Ends", Biochemical and Biophysical Research Communications, (1991), vol. 177, No. 1, 8-16.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK.sub.2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
D. Aharony et al., "Pharmacologic Characterization of the Novel Ligand Urinary Bladder Membranes", Neuropeptides, (1992), 23, 121-130.
M. Needham et al., "LCR/MEL: A Versatile System for High-Level Expression of Heterologous Proteins in Erythroid Cells", Nucleic Acids Research,(1992), vol. 20, No. 5, 997-1003.

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