Lactam compound

Details Lactam compound Lactam compound

2006-01-11

2008-12-23

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S523000

Reexamination Certificate

active

07468365

ABSTRACT:
The present invention provides crystalline (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, a crystalline anydrate and dihydrates thereof, compositions comprising (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, its crystalline anhydrate or dihydrate, and methods for using the same.

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Reiffen, Manred et al., Specific Bradycardic Agents. 1. Chemistry, Pharmacology, and Structure-Activity Relationships of Substituted Benzazepinones, a New Class of Compounds Exerting Antiischemic Properties, J. Med. Chem., 1990, 1496-1504, 33(5).
Devita, Roberg J. et al., Heterocyclic analogs of the Benzolactam Nucleus of the Non-Peptidic Growth Hormone Secretagogue L-692,429, Bioorganic & Medicinal Chemistry Letters, 1995, 1281-1286, 5(12).

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