Lactalbumin production process

Details Lactalbumin production process Lactalbumin production process

2006-05-30

2006-05-30

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

C530S350000, C530S300000, C530S394000, C530S365000, C530S414000, C530S416000, C426S580000, C426S583000, C435S007100

Reexamination Certificate

active

07053185

ABSTRACT:
A method for producing an oligomeric form of α-lactalbumin which is in the molten globule-like state is described. The method suitably comprises exposing a source of α-lactalbumin in which the α-lactalbumin is preferably in the molten globule-like state, to an ion exchange medium which has been pre-treated with casein or an active component thereof, such as oleic acid, and recovering α-lactalbumin in an oligomeric form therefrom. Pre-treatment of the ion exchange medium, particularly with casein derived from human milk, has been found to significantly improve yields of the oligomeric form of α-lactalbumin and means that it can be readily isolated from readily available sources such as bovine α-lactalbumin. This form of α-lactalbumin is useful therapeutically, in particular as an antibacterial agent and also as an anti-cancer therapeutic.

REFERENCES:
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