Labile derivatives of ketone analogs of 3-substituted-1-alkylami

Details Labile derivatives of ketone analogs of 3-substituted-1-alkylami Labile derivatives of ketone analogs of 3-substituted-1-alkylami

1989-09-18

1991-05-21

Dentz, Bernard I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

5142362, 514312, 514415, 514439, 514467, 514469, 514470, 514524, 514546, 514597, 514620, 514625, 514630, 514639, 514651, 544134, 546158, 549466, 549468, 549450, 549451, 549 30, 548182, 548146, 548200, 548201, 548503, 558422, 560142, 564 51, 564165, 564220, 564251, 564256, 564257, 564258, 564265, 564344, A61K 3115, C07C25138

Patent

active

050176188

ABSTRACT:
Compounds having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein --X-- is --O--, --CH.sub.2 -- or --; .dbd.Y is .dbd.O or a derivatized keto group which is hydrolyzable or enzymatically convertible to a keto group; R is alkyl having from 1 to 12 carbon atoms or aralkyl having from 7 to 20 carbon atoms; and Ar is the 3-aromatic or heterocyclic residue of a 1-alkylamino-2-propanol having an aromatic or heterocyclic substituent at the 3-position and having .beta.-adrenergic blocking properties; are useful as .beta.-adrenergic blocking agents and are of particular interest in the treatment of glaucoma or for lowering intraocular pressure.

REFERENCES:
patent: 4521414 (1985-06-01), Chiou et al.
Bodor et al, J. Med. Chem., vol. 31, No. 1, 1988, 100-106.
Ahmed et al, J. Pharm. Belg. 37(3), 214-217 (1982), abstracted in Chem. Abstracts, vol. 97, 188158n (1982).
Gnit'ko et al, Zh. Evol Biokhim Fiziol., 1972, 8(2), 194-201, abstracted in Chem. Abstracts, vol. 77, 70809j (1972).

Affiliated with

Also associated with

Rating

Labile derivatives of ketone analogs of 3-substituted-1-alkylami does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labile derivatives of ketone analogs of 3-substituted-1-alkylami, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labile derivatives of ketone analogs of 3-substituted-1-alkylami will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-238990