Labile anchors for solid phase polynucleotide synthesis

Details Labile anchors for solid phase polynucleotide synthesis Labile anchors for solid phase polynucleotide synthesis

1990-11-09

1992-05-12

Nucker, Christine

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

436524, 436527, 436 94, C07H 1512, C07H 1700, G01N 3300, G01N 33552

Patent

active

051129620

ABSTRACT:
This invention discloses a linker arm for solid support synthesis of oligonucleotides and oligonucleotide derivatives that allows the oligomers to be released relatively quickly under mild conditions. The linker arm comprises the following: ##STR1## The linker arm releases the oligomer in about one minute to about thirty minutes in a manner that leaves the oligonucleotide fully protected.

REFERENCES:
Matteucci et al., J. Amer. Chem. Soc., vol. 103: 3185-6 (1981).
Morrison et al., Organic Chemistry, Allyn and Bacon (1973) p. 606.

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