Labels, their production process and their uses

Details Labels, their production process and their uses Labels, their production process and their uses

2006-08-11

2011-10-11

Mui, Christine T (Department: 1774)

Chemistry: analytical and immunological testing

Optical result

Including reagent preparation

C436S164000, C436S174000

Reexamination Certificate

active

08034626

ABSTRACT:
The present invention relates to labels capable of forming a covalent or non-covalent bond with a target molecule, consisting of a dye to which there is bonded in a covalent manner by one or more carbons of its chemical structure:one or more [FUNC] group(s), andoptionally one or more [SOL] group(s),said label having the general formula:[DYE] representing the dye;[FUNC] each independently representing an —X-A-Z group, in which:X is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2group, R1and R2each being independently of each other a hydrogen atom or a linear or branched C1-C30, preferably C1-C18and more preferentially C1-C5alkyl group;A is chosen from the group consisting of an alkylene group or an alkylene-arylene group;Z is a reactive chemical function;[SOL] each independently representing an —X′-A′-Z′ group, in which:X′ is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2group, R1and R2each being independently of each other a hydrogen atom or a linear or branched C1-C30, preferably C1-C18and more preferentially C1-C5alkyl group;A′ is chosen from the group consisting of an alkylene group or an alkylene-arylene group;Z′ is a polar or apolar group.

REFERENCES:
patent: 4318846 (1982-03-01), Khanna et al.
patent: 4424201 (1984-01-01), Valinsky
patent: 4614723 (1986-09-01), Schmidt et al.
patent: 4882234 (1989-11-01), Lai et al.
patent: 5627027 (1997-05-01), Waggoner et al.
patent: 6225050 (2001-05-01), Waggoner
patent: 6291162 (2001-09-01), Tsien et al.
patent: 2002/0077487 (2002-06-01), Leung et al.
patent: 2005/0037332 (2005-02-01), Komatsu et al.
patent: 2005/0158804 (2005-07-01), Yao et al.
patent: 0 533 200 (1993-03-01), None
patent: 0 502 723 (1996-10-01), None
patent: 0 800 831 (1997-10-01), None
patent: 0 940 681 (1999-09-01), None
patent: 1 209 205 (2002-05-01), None
patent: 1 273 584 (2003-01-01), None
patent: 1 491 590 (2004-12-01), None
patent: 1 493 781 (2005-01-01), None
patent: 1 559 374 (2005-08-01), None
patent: 2 748 027 (1997-10-01), None
patent: 2 764 605 (1998-12-01), None
patent: 58/217569 (1983-12-01), None
patent: 63/277680 (1988-11-01), None
patent: 01/239548 (1989-09-01), None
patent: 03/228046 (1991-10-01), None
patent: 04/080749 (1992-03-01), None
patent: 06345794 (1994-12-01), None
patent: 03/133628 (2003-05-01), None
patent: 03/133629 (2003-05-01), None
patent: WO90/02747 (1990-03-01), None
patent: WO92/08720 (1992-05-01), None
patent: WO94/08631 (1994-04-01), None
patent: WO95/07888 (1995-03-01), None
patent: WO95/08772 (1995-03-01), None
patent: WO96/10620 (1996-04-01), None
patent: WO97/06829 (1997-02-01), None
patent: WO97/39064 (1997-10-01), None
patent: WO98/30720 (1998-07-01), None
patent: WO98/30992 (1998-07-01), None
patent: WO99/07793 (1999-02-01), None
patent: WO99/55805 (1999-11-01), None
patent: WO00/16810 (2000-03-01), None
patent: WO00/63296 (2000-10-01), None
patent: WO02/24815 (2002-03-01), None
patent: WO02/32466 (2002-04-01), None
patent: WO03/082988 (2003-10-01), None
patent: WO2004/011556 (2004-02-01), None
patent: WO2004/039810 (2004-05-01), None
patent: WO2004/065491 (2004-08-01), None
patent: WO2005/019470 (2005-03-01), None
patent: WO2005/058370 (2005-06-01), None
Internationl Preliminary Report on Patentability of PCT/FR2006/001947, PCT, pp. 1-28.
Cai et al., “Nucleic Acid-Triggered Fluorescent Probe Activation by the Staudinger Reaction”,J. Am. Chem. Soc., 2004, 126, pp. 16324-16325, XP-002415886.
Caturla et al., “New fluorescent process for testing combinatorial catalysts with phosphodiesterase and esterase activities”,Tetrahedron60 (2004) pp. 1903-1911, XP-002415885.
Corrie et al., “Synthesis of photoactivatable fluorescein derivatives bearing side chains with varying properties”,Journal of the Chemical Society, XP-002415916 (Abstract Only).
Jackson et al., “Pyrroles and related compounds. XIII. Porphyrin synthesis through b-oxobilanes and oxophlorins (oxyporphyrins)”,Journal of the Chemical Society, XP-002426744 (Abstract Only).
Jackson et al., “Synthesis of gamma-oxyprotoporphyrin IX and pterobiline (biliverdin IX gamma)”,Journal of the Chemical Society, XP-002426746 (Abstract Only).
Kasai et al., “Glycosides having chromophores as substrates for sensitive enzyme analysis. V. Synthesis of 6′-O-substituted 2′, 7′-dichlorofluorescein N-acetyl-beta-D-glucosaminides as substrates for the rate-assay of N-acetyl-beta-D-glucosaminidase”,Chemical&Pharmaceutical Bulletin(1993), 41(9), 1513-20, XP-002415917 (Abstract Only).
Kenner et al., “Pyrroles and related compounds. XVI. Synthesis of protoporphyrin IX by and a- and b-oxobilane routes”,Journal of the Chemical Society, XP-002426745 (Abstract Only).
Kobayashi et al., “Silver halide photographic material containing sensitizing dye”,Jpn. Kokai TokkyoKoho, XP-002426743 (Abstract Only).
Krafft et al., “Photoactivable Fluorophores. 3. Synthesis and Photoactivation of Fluorogenic Difunctionalized Fluoresceins”,J. Am. Chem. Soc.1988, 110, pp. 301-303, XP-002415887.
Lobnik et al., “pH optical sensors based on sol-gels: Chemical doping versus covalent immobilization”,Analytica Chimica Acta, 367 (1998) pp. 159-165, XP-002382764.
Lu et al., “Synthesis and characterization of novel sandwich-type lanthanide (III) complexes with mixed [tetrakis(4-chlorophenyl)porphyrinato] and [(alpha-octa-butoxy)phthalocyaninato] ligands”,Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-MetalChemistry (2005), 35(6), pp. 463-467, XP-002426750 (Abstract Only).
Moreau et al., “Synthese d'indomonocarbocyanines a elimination biliaire selective Etude experimentale chez l'animal”,Eur. J. Med. Che—Chimica Therapeutica, May-Jun. 9, 1974, No. 3, pp. 274-280, XP-008070191.
Pandian et al., “Novel particulate spin probe for targeted determination of oxygen in cells and tissues”,Free Radical Biology&Medicine(2003), 35(9), 1138-1148, XP-002426749 (Abstract Only).
Smith et al., “Novel porphyrins from copper (II)-mediated cyclizations of 1′, 8′-dimethyl-A, C-biladiene salts: mechanism of the cyclization reaction”,Journal of Organic Chemistry, (1985) 50(12), 2073-80, XP-002426747 (Abstract Only).
Ueno et al., “Preparation of metal-porphyrin complexes catalyzing oxidation reaction as labeling agents for trace detection of DNA and proteins”,Jpn. Kokai Tokkyo Koho, XP-002426748 (Abstract Only).
XP-002415915 Beilstein Data: Copyright © 1988-2006, Beilstein Institut zur Foerderung der Chemischen Wissenschaften licensed to Beilstein GmbH and MDL Information Systems GmbH. All rights reserved.
Masiero et al., “G-Quartets as a Self-Assembled Scaffold for Circular Porphyrin Arrays,”Chemical Communications, vol. 20, pp. 1995-1996 (2000).
Yu et al., “Porphyrin Capped Ti02 Nanoclusters, Tyrosine Methyl Ester Enhanced Electron Transfer,”Chemical Communications, vol. 15, pp. 1856-1857 (2003).
Chaleix et al., “RGD-Porphyrin Conjugates: Synthesis and Potential Application in Photodynamic Therapy,”European Journal of Organic Chemistry, vol. 8, pp. 1486-1493 (2003).

Affiliated with

Also associated with

Rating

Labels, their production process and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labels, their production process and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labels, their production process and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4272850