Labelling of hormones with rhenium and tecnetium

Details Labelling of hormones with rhenium and tecnetium Labelling of hormones with rhenium and tecnetium

1993-04-12

1996-09-10

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to cyclopentano-hydrophenanthrene ; derivative thereof

514182, 552618, 552629, 552630, 552631, C07J 100, A61K 31565

Patent

active

055546021

ABSTRACT:
The disclosed invention is drawn to the organometallic oestrogen complex of formula (I): ##STR1## in which A is a C.sub.1-7 alkylene radical or C.sub.2-7 alkenylene or alkynylene radical; M.sub.x is one or more identical or different transition metals; L'.sub.y is one or more identical or different ligands complexing the metal(s) of M.sub.x ; and L is a ligand for covalently coupling M.sub.x to A; and R is H or a C.sub.1-7 alkyl or alkoxy group which may be optionally substituted, particularly with one or more halogens. These complexes are useful for the treatment of hormone-dependent cancers. Also, when the metals of the complex M.sub.x are radioactive isotopes suitable for imaging, the complexes are useful as imaging agents.

REFERENCES:
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patent: 5427766 (1995-06-01), Dowd
S. Top et al., "Reactions of eq, eq-Re2(CO)8(MeCn)2 with Phenylacettlene and alpha-Ethynylestradiol. A New Synthesis of Acetylide Complexes", J. Organometallic Chem., vol. 414, No. 1, Aug. 13, 1991.
G. Jaouen et al., "Transition Metal Carbonyl Oestrogen Receptor Assay", Pure & Applied Chemistry, vol. 57, No. 12, Dec. 1985, London, GB, pp. 1865-1874.
S. Top et al., "Synthetic, Structural, and Reactivity Studies of Di-Rhenium Carbonyl Complexes of 17-alha-Ethynylestradiol & Phenylacetylene: . . . ", Organometallics, vol. 11, No. 3, US, pp. 1201-1209 (1992).

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