Labelling compounds for the simple synthesis of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S028540, C514S050000

Reexamination Certificate

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06891033

ABSTRACT:
The application relates to compounds that are suitable as labelable precursors for synthesis of 3′-[18F]fluoro-3′-deoxythymidine and that have formula (1),in whichR denotes triphenylmethyl, triphenylmethyl substituted in the phenyl group, trialkylmethyl, triphenylsilyl, triphenylsilyl substituted in the phenyl group, or trialkylsilyl,R′ denotes R1—SO2, where R1is an unsubstituted or substituted C1to C5alkyl or an unsubstituted or substituted phenyl, andR″ denotes C2to C10alkyloxycarbonyl, with the exception of 3-N-Boc-1-(3-O-nosyl-5-O-trityl-2-deoxy-β-D-lyxofuranosyThe application also relates to a method for preparation of these compounds and to the use of the same for synthesis of 3′-[18F]fluoro-3′-deoxythymidine.

REFERENCES:
patent: 5561225 (1996-10-01), Maddry et al.
patent: 20020102013 (2002-08-01), Gosselin et al.
patent: 694 07 419 (1998-07-01), None
European Journal of Nuclear Medicine, vol. 27 (8), p. 1220, 2000 (Abstract Only)).*
Sanghvi et al. (WO 01/73095 A2) (Abstract Sent).*
Schreiber et al. (Tetrahedron Letters (1988), 29(26), 3211-14) (Abstract Sent).*
International Search Report (PCT/EP02/00865)—3 pages.
Eisenbarth et al., “Precursors of [18F]FLT: Development of Simple Synthetic Pathways,” Euopean Journal of Nuclear Medicine, vol. 27(8), pp. 1220, 2000 (XP-002199400).
Grierson, Jr. et al., “Developments in the Radiosynthesis of [F-18]FLT,” Journal of Nuclear Medicine, vol. 39(5), pp. 22P, 1998 (XP-008003383).
Grierson, Jr. et al., “Radiosynthesis of 3'-Deoxy-3'[18F]flourothymidine: [18F]FLT for Imaging of Cellular Proliferation In Vivo,” Nuclear Medicine & Biology, vol. 27, pp. 143-156, 2000 (XP-002199401).
Wilson et al., “Synthesis of 3'-flouro-3'-***Deoxythymidine*** and Studies of its Fluorine-18 Radiolabeling, as a Tracer for the Noninvasive Monitoring of the Biodistribution of Drugs Against AIDS,” J. Flourine Chem., vol. 55(3), pp. 283-289, 1991 (Chemical Abstract Only).

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