Labelled vitamin D.sub.3 derivative and production process there

Details Labelled vitamin D.sub.3 derivative and production process there Labelled vitamin D.sub.3 derivative and production process there

1989-09-07

1992-05-26

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

552653, 514167, A61K 4300, A61K 4902, A61K 3159, C07C 1315

Patent

active

051165732

ABSTRACT:
The present invention discloses a novel, labelled vitamin D.sub.3 derivative in which hydrogen atoms on the skeleton portion, i.e. 6- and 19-positions, are substituted with a deuterium atom or a tritium atom, as well as a novel production process of the labelled vitamin D.sub.3 derivative carried out by way of sulfur dioxide addition reaction of a vitamin D.sub.3 derivative. The labelled portion of the novel vitamin D.sub.3 is resistant against in vivo metabolism and make a long period tracing of its pharmacodynamics in a living body possible.

REFERENCES:
patent: 4898855 (1990-02-01), Baggiolini et al.
Yamada et al., Steroids, 54(2), pp. 145-157, Aug. 1989.
Yamada et al., J. Org. Chem., 48(20), 3484-88, 1983.
Yamada et al., Tetrahedron Letters, 22(32), pp. 3085-3088, 1981.
Reischl et al., Helvetica Chimica Acta, 62(6), pp. 1763-1769, 1979.

Affiliated with

Also associated with

Rating

Labelled vitamin D.sub.3 derivative and production process there does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labelled vitamin D.sub.3 derivative and production process there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labelled vitamin D.sub.3 derivative and production process there will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-418006