Labelled phospholipid material colloidially dispersed and sized

Details Labelled phospholipid material colloidially dispersed and sized Labelled phospholipid material colloidially dispersed and sized

1975-01-07

1976-11-16

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

128 2A, 250303, 2523011R, 252311, 252312, 260403, A61K 2900, A61K 4300, A61B 1000, A23J 700

Patent

active

039925137

ABSTRACT:
A carrier is disclosed for diagnostic scanning agents labelled with short-lived radioisotopes for medical organ studies which comprises colloidally dispersed phospholipid material, and also disclosed are new diagnostic scanning agents utilizing the carrier and a radioisotope, preferably .sup.99m Tc, which is in a form which complexes with the carrier. The radioisotope labelling can be carried out directly before use, the carrier in dispersed form being stable for a considerable period of time. Methods of preparation of the scanning agents are also disclosed which provide a material which localizes mainly in the liver after injection, or alternately at least initially in the lungs when an aggregating agent is used during preparation in a specific sequence of steps. Specific organ scans or sequential scanning is thus possible.

REFERENCES:
patent: 3597455 (1971-08-01), Arons et al.
patent: 3663685 (1972-05-01), Evans
patent: 3863004 (1975-01-01), Wolfangel
patent: 3872226 (1975-03-01), Haney et al.

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