Labelled nucleotides

Details Labelled nucleotides Labelled nucleotides

2010-06-21

2011-12-27

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S026600, C435S006120

Reexamination Certificate

active

08084590

ABSTRACT:
The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl). T is hydrogen or a C1-10substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).

REFERENCES:
patent: 4711955 (1987-12-01), Ward et al.
patent: 4772691 (1988-09-01), Herman
patent: 5302509 (1994-04-01), Cheeseman
patent: 5436143 (1995-07-01), Hyman
patent: 5516664 (1996-05-01), Hyman
patent: 5547839 (1996-08-01), Dower et al.
patent: 5602000 (1997-02-01), Hyman
patent: 5763594 (1998-06-01), Hiatt et al.
patent: 5872244 (1999-02-01), Hiatt et al.
patent: 6008379 (1999-12-01), Benson et al.
patent: 6087095 (2000-07-01), Rosenthal et al.
patent: 6214987 (2001-04-01), Hiatt et al.
patent: 6255475 (2001-07-01), Kwiatkowski
patent: 7414116 (2008-08-01), Milton et al.
patent: WO 91/06678 (1991-05-01), None
patent: WO 92/10587 (1992-06-01), None
patent: WO 94/14972 (1994-07-01), None
patent: WO 96/07669 (1996-03-01), None
patent: WO 99/05315 (1999-02-01), None
patent: WO 99/57321 (1999-11-01), None
patent: WO 00/02895 (2000-01-01), None
patent: WO 0015844 (2000-03-01), None
patent: WO 00/53812 (2000-09-01), None
patent: WO 01/23610 (2001-04-01), None
patent: WO 01/57249 (2001-08-01), None
patent: WO 02/29003 (2002-04-01), None
Oksman, P. et al, Solution conformations and hydrolytic stability of 2′- and 3′-substituted 2′, 3′-dideoxyribonucleosides, including some potential inhibitors of human immunodeficiency virus, Journal of Physical Organic Chemistry, 1992, vol. 5, No. 11, pp. 741-747.
Zavgorodny, S. et al, 1-Alkylthioalkylation of nucleoside hydroxyl functions and its synthetic applications: a new versatile method in nucleoside chemistry, Tetrahedron Letters, 1991, vol. 32, No. 51, pp. 7593-7596.
Oksman, P. et al, Conformation of 3′-substituted 2′, 3′-dideoxyribonucleosides in aqueous solution: nucleoside analogues with potential antiviral activity, Nucleosides & Nucleotides, 1991, vol. 10, No. 1-3, pp. 567-568.
M. Kloosterman, J.H. Van Boom, P. Chatelard, P. Boullanger, and G. Descotes, The Relative Stability of Allyl Ether, Allyloxycarbonyl Ester and Prop-2 Enylidene Acetal protective groups toward Iridium, Rhodium and Palladium Catalysts., Tetrahedron Letters, vol. 26, No. 41, (pp. 5045-5048) 1985.
Kocienski, Protecting Groups, Georg Tieme Verlag, Stuttgart, (pp. 61-68) 1994.
G.H. Veeneman, G.A. Van Der Marel, H. Van Den Elst and J.H. Van Boom, An Efficient Approach to The Synthesis of Thymidine Derivatives Containing Phosphate-Isosteric Methylene Acetal Linkages, vol. 47, No. 8 (pp. 1547-1562) 1991.
Masato Kitamura, Shinji Tanaka and Masahiro Yoshimura, CpRu -Catalyzed Deprotrctopn of Allyl Carboxylic Esters, American Chemistry Society, vol. 67 No. 14, (pp. 4975-4977) 2002.
Francois Guibe, Allylic Protecting Groups and Their use in a Complex Environment Part II: Allylic Protecting Groups and Their Removal Through Catalytic Palladium Allyl Methodology, Tetrahedron NL vol. 53 No. 13, (pp. 2967-3042) 1997.
Yoshihiro Hayakawa, Masaaki Hiroea and Ryoji Noyori, Allyl Protection of Guanine and Thymine Residues in Oligodeoxyribonucleotides, J of Organometallic Chemistry, vol. 58 JOC, (pp. 5551-5555) 1993.
Francois Guibe, Allylic Protecting Groups and Their use in a Complex Environment Part I: Allylic Protection of Alcohols, Tetrahedron NL, vol. 53 No. 40, (pp. 13509-13556) 1997.
Frank Bergmann, Erich Kueng, Patrick Iaiza and Willi Bannwarth, Allyl as Internucleotide Protecting Group in DNA Synthesis to be Cleaved off by Ammonia, Tetrahedron NL, vol. 51 No. 25 (pp. 6971-6976) 1995.
Green, Protective Groups in Organic . . . , John Wiley & Sons NY, (pp. 67-74 & 574-576) 1999.
J. Brunckova et al., Tetrahedron Letters, (1994), vol. 35, pp. 6619-6622.
S. Nishino et al., Heteroatom Chemistry, (1991), vol. 2, pp. 187-196.
M. Kre{hacek over (c)}merováet al., Collect. Czech. Chem. Commun., (1990), vol. 55, pp. 2521-2536.
P. J. L. M. Quaedflieg et al., Tetrahedron Letters, (1992), vol. 33, No. 21, pp. 3081-3084.
J. I. Yamashita et al., Chem Pharm. Bull., (1987), vol. 35, pp. 2373-2381.
S.G. Zavgorodny et al., Nucleosides, Nucleotides & Nucleic Acids, (2000), 19(10-12), 1977-1991.
Kraevskii et al., Substrate Inhibitors of DNA Biosynthesis, Translated from Molekulyarnaya Biologiya [Mol. Bio. (Mosk.)] 21:33-38 (1987).
Henner et al., Enzyme Action at 3′ Termini of Ionizing Radiation-induced DNA Strand Breaks, The Journal of Biological Chemistry, 258:15198-15205 (1983).

Affiliated with

Also associated with

Rating

Labelled nucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Labelled nucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labelled nucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4311860