Labelled interleukin-8 and medical uses thereof

Details Labelled interleukin-8 and medical uses thereof Labelled interleukin-8 and medical uses thereof

1992-10-05

1994-09-13

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to lymphokine, cytokine, or other secreted growth...

A61K 4902

Patent

active

053466861

ABSTRACT:
A method of imaging a target site in an animal's body in which a labelled CXC chemokine is introduced into the animal's body and allowed to accumulate at a target site which includes Interleukin-8 receptor molecules. The accumulated, labelled CXC chemokine is then detected so as to image the target site of the body.

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Darbonne et al., "Red Blood Cells Are a Sink for Interleukin 8 . . . ," J. Clin. Invest. 88, Oct. 1991, pp. 1362-1369.
Grob et al., "Characterization of a Receptor for Human Monocyte-Derived Neutrophil Chemotactic Factor/Interleukin-8," J. Biol. Chem. 265(14) May 15, 1990, pp. 8311-8316.

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