Labelled compound

Details Labelled compound Labelled compound

1996-03-22

1998-12-08

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

435106, C07C25511, C07C25527, C12P 1304

Patent

active

058471936

ABSTRACT:
The present invention provides a labelled .beta.-cyano-L-alanine and a .gamma.-cyano-.alpha.-aminobutyric acid, of which cyano group carbon is labelled with radionuclide .sup.11 C or .sup.14 C, or stable isotope .sup.13 C. The present invention also provides a labelled amino acids such as asparagine, asparatic acid, DABA, GABA, glutamine and glutamic acid synthesized by using the labelled .beta.-cyano-L-alanine and the .gamma.-cyano-.alpha.-aminobutyric acid as an intermediate. The labelled amino acids are useful for in vivo imaging of tumors and brain functions.

REFERENCES:
G. Antoni et al., Eleventh International Symposium on Radiopharmaceutical Chemistry, Abstracts, pp. 182-183 (1995).
Chem ABS 104: 1493682 Rohm et al J. Labelled Compd. Radiopharm 1985 22(9) 909-15.
Chem ABS 116: 55130m Willhardt et al DD291,579 Jul. 4, 1991.
Chem ABS 71:98987 & Ressler et al Biochem Biophy Acta 184(3) 578-82 (1969).
Chem ABS 116: 124278e Hermann et al "Enzymes Depend." Proce Int Symp. Vitam B6 Carbonyl Catal 8.sup.th 1990, 649-56.

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