Labelled cardiotonic glycosides for use in radioimmunoassay

Details Labelled cardiotonic glycosides for use in radioimmunoassay Labelled cardiotonic glycosides for use in radioimmunoassay

1974-08-29

1976-06-15

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424182, C07J 1900

Patent

active

039636976

ABSTRACT:
Disclosed are radioactive cardiotonic glycosides and a process of making such glycosides, the compounds being useful for radioimmunoassay of body fluids for cardiotonic glycoside content.
The novel synthesis comprises reaction of a hydroxyl group of the sugar with a dicarboxylic acid derivative such as a diacid, diacid anhydride or a diacyl halide and thereafter reacting the free carboxylic group with a compound which will undergo electrophilic substitution reactions. A radioactive isotope, preferably .sup.125 I, is reacted via electrophilic substitution with the compound to form the radioactive cardiotonic glycoside.

REFERENCES:
patent: 3843628 (1974-08-01), Minato
Chem. Abstracts, vol. 80, No. 1-2, "PharmacoDynamics", 10141 N, 1974.
Analytical Chemistry, "Radioimmunoassay", vol. 45, No. 11, p. 882, Sept. 1973.
Morrison and Boyd, "Organic Chemistry", Allyn & Bacon, Inc., Boston, 1966, p. 360.

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