Labelled acyl-L-carnitine and diagnostic agent

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

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424 111, 424 165, A61K 3700, A61M 3614

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active

058372199

ABSTRACT:
The present invention provides a labelled acyl-L-carnitine, which is an acyl-L-carnitine, a salt thereof or a derivative thereof, of which carbon group is labelled with a radionuclide or a stable isotope. It is possible to diagnose human diseases falling under acyl-carnitine metabolic syndrome, or human diseases due to structural/functional disorder of the brain by measuring the behavior of the labelled acyl-L-carnitine in various tissues or a biological sample from a subject administered with one or more kinds of the labelled acyl-L-carnitines.

REFERENCES:
Davenport (1995), Nuclear Medicine and Biology, vol. 22, No. 6, pp. 699-709 "Propionyl-L-Carnitine: Labeling in the N-Methyl Position with Carbon-11 and Pharmacokinetic Studies in Rats."
Sherry et al (1985), J. Biological Chemistry, vol. 260, No. 16, pp. 9272-9279, "Metabolic Studies of Pyruvate-and Lactate-Perfused Guinea Pig Hearts by .sup.13 C NMR".
Sherry et al (1988), Biochem. J, vol. 254, pp. 593-598, "Propionate Metabolism in the Rat Heart by .sup.13 C n.m. r. Spectroscopy".
Anderson et al (1995), vol. 117, No. 42, pp. 10546-10550, J. Am. Chem. Soc. Rotational-Echo, Double-Resource Nuclear Magnetic Resonance Spectroscopy".

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