Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1996-10-30
1998-11-17
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 165, A61K 3700, A61M 3614
Patent
active
058372199
ABSTRACT:
The present invention provides a labelled acyl-L-carnitine, which is an acyl-L-carnitine, a salt thereof or a derivative thereof, of which carbon group is labelled with a radionuclide or a stable isotope. It is possible to diagnose human diseases falling under acyl-carnitine metabolic syndrome, or human diseases due to structural/functional disorder of the brain by measuring the behavior of the labelled acyl-L-carnitine in various tissues or a biological sample from a subject administered with one or more kinds of the labelled acyl-L-carnitines.
REFERENCES:
Davenport (1995), Nuclear Medicine and Biology, vol. 22, No. 6, pp. 699-709 "Propionyl-L-Carnitine: Labeling in the N-Methyl Position with Carbon-11 and Pharmacokinetic Studies in Rats."
Sherry et al (1985), J. Biological Chemistry, vol. 260, No. 16, pp. 9272-9279, "Metabolic Studies of Pyruvate-and Lactate-Perfused Guinea Pig Hearts by .sup.13 C NMR".
Sherry et al (1988), Biochem. J, vol. 254, pp. 593-598, "Propionate Metabolism in the Rat Heart by .sup.13 C n.m. r. Spectroscopy".
Anderson et al (1995), vol. 117, No. 42, pp. 10546-10550, J. Am. Chem. Soc. Rotational-Echo, Double-Resource Nuclear Magnetic Resonance Spectroscopy".
Kitani Teruo
Kuratsune Hirohiko
Langstrom Bengt
Watanabe Yasuyoshi
Hollinden Gary E.
Japan Science and Technology Corporation
Jones Dameron
LandOfFree
Labelled acyl-L-carnitine and diagnostic agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Labelled acyl-L-carnitine and diagnostic agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Labelled acyl-L-carnitine and diagnostic agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-881201